Abstract: Health and disease are two terms we daily come across and we know the importance of good health. Various biochemical reactions are continuously going inside the human body to repair, rejuvenate, refresh and heal our body from the cellular level. It has been observed that nowadays due to tech-savvy lifestyle and to get immediate result people are more dependent on medicines to remain fit. No doubt, medicines give quick relief but we can not ignore & deny side effects caused after consuming them. Acetaminophen is a drug worldwide used by people as a pain killer, to reduce pain and fever and is easily available in different names like Tylenol, Calpol, Panadol, and Dolo 650 Tablet. Prolong, overdose, or regular use of Acetaminophen may be poisonous and results in chronic effects like anemia, may cause dizziness, skin pallor, light-headedness, fast heartbeat, and may even damage to liver & kidneys. Very less is known about its pharmacodynamics. Medicinal plants contain particular alkaloids with bioactive compounds which are beneficial for mankind for treating many diseases without causing any harm to our vital organs and they are the ray of hope amidst pandemic time too. Tulsi, Ginger, Turmeric, Neem are easily available everywhere and hence can be used as an effective substitute for Acetaminophen. The study is conducted on rural tribal people of Uttarakhand India. A total of one hundred sixteen respondents were questioned and it was analyzed that 55.2% of people understand that too much use of paracetamol for extended periods can damage the liver. 45.7% of people have used plant-based medications for the immediate cure of aches and pains instead of medicines. The study reveals that curative herbs are a better substitute because they possess antioxidants, antibacterial properties because of dissolved alkaloids in them. This study is based on current knowledge of Science and can be easily implementable.

Keywords: Acetaminophen; Pharmacodynamics; Curative herbs

| DOI: 10.17148/IARJSET.2021.8901