Abstract: Macrocyclic compounds have attracted increasing interest owing to their role in understanding of molecular processes occurring in biochemistry, material science, and catalysis. It is well known that N atoms play a key role in the coordination of metal at the active sides of numerous metallobiomolecules. Macrocycles can selectively bind different cations in agreement with the size of the cycle, as well as the nature and number of the heteroatoms belonging to the cycle. Hydrazone Schiff bases of acyl, aroyl and hetero aroyl compounds have additional donor sites like C=O. The additional donor sites make them more flexible and versatile.
Nitrogen-containing macrocycles were synthesized in quantitative yield by reacting carbohydrazide and dialdehydes which were derived from salicylaldehyde by cyclocondensation. All the newly synthesized compounds were characterized by elemental analysis, IR, NMR and Mass spectroscopy.

Keywords: Macrocycles, Hydrazones, bis-Schiff bases, Carbohydrazide Derivatives.

| DOI: 10.17148/IARJSET.2022.9112