Abstract: A new schiff base ligand, 1H-5-chloro-indole-2-one-3-(2-methyl-4-nitro)-anilinimine was synthesised by the condensation of 2-methyl-4-nitro aniline with 5-chloro isatin. Cu(II) and Zn(II)metal complexes were prepared by refluxing the above synthesised ligand with Chlorides, nitrates and acetates of the respective metals. The complexes were characterised by various physicochemical techniques such as elemental analysis, FT IR, 1H NMR, UV visible, TGA, conductivity and magnetic susceptibility measurements. The ligand acts as bidentate in which the carbonyl oxygen and the azomethine nitrogen are involved in chelation. Square planar geometry for Cu(II) complexes and Tetrahedral geometry was proposed for Zn(II) complexes. The ligand and complexes were screened for their antimicrobial and antifungal activities.

Keywords: Chloro isatin, Schiff base, antibacterial, antifungal.

| DOI: 10.17148/IARJSET.2022.9269