ABSTRACT: CHROMIUM (Cr) is a natural heavy metal, found in different forms such as Cr III and Cr VI. The Cr VI (hexavalent Cr) is the most common forms and otherwise termed as potassium dichromate (K2Cr2O7), which is generally located in the brownfields, public distribution water systems, surface and subterranean waters throughout the industrialized world. The exposure of Cr VI in these areas may causes tissue damage (testis, spleen, kidney and liver). Our present study to focussed to work with liver and kidney tissues. Therefore, the injuries of renal and hepatic tissues are crucial for altering the lipid profiles on the exposure of Cr VI toxicity. Hence, consideration plant extracts like Cucumis melo L. fruits have been used in our current study. This plant extract is vital for regulating the antioxidant and antihyperlipidemic activity. Therefore, the aim of the present study was to investigate the possible antihyperlipidemic activity of Cucumis melo L. whole fruit aqueous extract in Cr VI induced in rats. Treatment with fruit aqueous extract showed significant (P

| DOI: 10.17148/IARJSET.2021.8875