Abstract: Diabetes mellitus is becoming increasingly common in both developed and developing countries around the world. Existing treatments, particularly synthetic pharmaceuticals, frequently fail to restore normal glycemic control without side effects. A variety of herbal medications are being studied as an alternative therapy for diabetes. The goal of this study was to test one such herbal extract of Benincasa hispida seed for anti-diabetic efficacy in diabetic rats that had been artificially generated. The extract at a dose 500mg/kg/day was administered to Alloxan induced diabetic animals for 15 consecutive days. Blood glucose levels and body weight were measured for the evaluation of its anti-diabetic effect. Our study indicates that ethanolic extract of Benincasa hispida seed has a promising effect in controlling blood glucose levels and also aid in counteracting the derangement of lipid profile, a major concern in diabetes mellitus.

Keywords: Benincasa hispida, Ethanolic extract, Wistar rats.

| DOI: 10.17148/IARJSET.2021.8598