Abstract: Aims: In the present study, an ethanolic leaves extract of Moringa Oleifera was examined for its antiulcer potential in experimental albino rats using two models: ethanol induced and pylorus ligation-induced gastric ulceration. The extract was orally administered at three different doses (100, 150, and 250mg/kg) for 15 consecutive days. The anti-ulcer effect in rats treated with different doses of Moringa oleifera leaves extract and omeprazole (30 mg/kg, p.o.). The study was carried out between November 2020 to February 2021 in the Pharmacology Laboratory of Department of Pharmacology. Bharat Technology, West Bengal, India, Methodology: The ethanol leaf extract of Moringa Oleifera was prepared. The doses of the extract administered to the rats were 100,150, 250 mg/kg body weight respective, Ulcer was induced with diclofenac sodium (100mg/kg; b.w.). omeprazole (30 mg/kg, p.o.) were determined and statistically compared with the anti-ulcer effects in the control rats treated with saline (NaCl, 0.9%). The MO at doses of 100, 150 and 250 mg/kg decreased the ulcer index significantly as compared to the control group (p

| DOI: 10.17148/IARJSET.2021.8599