Abstract: The aim of this present research work is formulation and evaluation of herbal cream of the flowers of Calendula officinalis with antibacterial activity. Antibacterial activity is the process of killing or inhibit the disease causing by microbes. The study is to prepare the herbal cream for the use of anthelmintic activity, anti-inflammatory activity, wound healing activity, analgesic activity, antibacterial activity and recovery various disease of the skin. Method of prepare herbal cream is very simple. At first oil phase prepared stearic acid, cetyl alcohol, potassium hydroxide ware melted at 70℃. After that aqueous phase is papered, lanolin, drug (ethanolic extract of Calendula officinalis), ethanol, glycerin, distilled water, methyl paraben, perfume heated at 70℃.Than aqueous phase is added in to the oil phase with continuous stirring. After that the mixture is put in room temperature with continuous stirring and added perfume and preservatives and transfer the cream in a suitable container. The evaluation parameter is determined such as pH, thermal stability, homogeneity, irritancy test, patch test, spreadability studies, accelerated stability testing etc. The further studies formulation, evaluation & antibacterial activity will be carried out bellow.

Keywords: Calendula officinalis, herbal cream, antibacterial activity.

| DOI: 10.17148/IARJSET.2021.8569