NOVEL SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF COMPLEXES OF Mn (II), Ni (II) AND Cu (II) WITH 3-NITROBENZALDEHYDE THIOSEMICARBAZONE

Abstract: A series of novel 3-Nitrobenzaldehyde thiosemicarbazone complexes with three transition metal i.e. Mn(II), Ni(II) and Cu(II) having the general composition [Mn(3NBT)2Cl2], [Ni(3N BT)2Cl2] and [Cu(3NBT)2Cl2]{where 3NBT= 3-Nitrobenzaldehyde thiosemicarbazone, have been synthesized by the reaction of thiosemicarbazide with 43-Nitrobenzaldehyde by conventional heating as well as microwave irradiations method followed by complexation with transition metals. The synthesized compounds have been characterised by elemental analysis, melting point determination, FTIR, UV-visible spectral analysis. The synthesized ligands and their new metal complexes have been screened in vitro for antibacterial activity against Escherichia coli, Staphylococcus aureus and Bascillus subtilis bacteria.

Keywords: Thiosemicarbazones, Microwave irradiation, Transition metal complexes.