Abstract: ODTs are solid dosage forms containing medicinal substances which is easily disintegrate in the mouth within few seconds. The products of ODT technologies are taking place in the market in the 1980s, as the development of the drug delivery system in the pharmaceutical industry the popularity of ODTs products is continuously increased. ODTs products demand is increased in the market because of a preferred alternative to conventional tablets and capsules and great impact on patient willingness especially for the pediatrics, geriatric, and psychiatric patients with dyspepsia. Ibuprofen is a non-steroidal anti-inflammatory drug. It is widely used in children to defeated pain, fever, and inflammation. Due to its quick onset of analgesic effects and optimum serum concentration, it is the most preferred drug of choice for pediatric formulations. In our research work, the wet granulation technique is chosen for the preparation of granules and super-disintegrant like crospovidone and sodium starch glycolate has been added in the intragranular portion to get faster disintegration of tablets. All the physical evaluation parameters of tablets are checked and found within the limit in every formulation except the disintegration time which is achieved in the final formula. It has been found from the experiment that with the increase in the concentration of super disintegrant, the time of disintegration of tablet decreases, and the percentage drug release profile increases. In the final formulation, the desired target of disintegration time is achieved and also good release profile in the dissolution studies is found. Since Ibuprofen is a bitter drug so it is required to optimize the concentration of sweetening agent in the formulation and also further investigation will be carried out to optimize the effect of formulation processing variables on the preparation of tablets.

Keyword: - Ibuprofen, Oral Disintegrating Tablet, Super Disintegrant, Tablets, Pediatric, Granules, Geriatric.

PDF | DOI: 10.17148/IARJSET.2021.86110

Open chat