SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-[(3-PHENYL-5-THIOXO-1,5-DIHYDRO-4H-1,2,4-TRIAZOL-4-YL)IMINO]-1,3-DIHYDRO-2H-INDOLE-2-ONE
Abstract: A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2H-indole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds was elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Keywords: Indole, Triazole, nucleophilic substitution, Antibacterial activity.
How to Cite:
[1] Neelotlma Singh and Amit Chattree, “SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-[(3-PHENYL-5-THIOXO-1,5-DIHYDRO-4H-1,2,4-TRIAZOL-4-YL)IMINO]-1,3-DIHYDRO-2H-INDOLE-2-ONE,” International Advanced Research Journal in Science, Engineering and Technology (IARJSET), DOI: 10.17148/IARJSET.2016.31136
This work is licensed under a Creative Commons Attribution 4.0 International License.