SYNTHESIS OF FORMAZAN DERIVATIVES ANTIMICROBIAL STUDY AND PHYSICOCHEMICAL PROPERTIES IN BINARY SOLVENT SYSTEM

Abstract: Formazan derivatives plays vital role in medicinal chemistry because of supreme biological activity. In this study formazan derivatives were synthesized in cold condition. Spectral interpretation was used to characterize the structure of synthesized compounds. Physicochemical properties were studied in binary solvent system using viscometric measurement. Increase in solute-solvent interactions was interpreted from increase in viscosity. Conductivity measurements and antibacterial activity against gram positive and gram negative pathogens were carried out for all derivatives in different solvent systems. E-Coli and S. Aureus shows good activity towards 3 -phenyl -(4 chlorophenyl)-5-phenyl formazan than 3 -phenyl -(4 nitrophenyl)-5-phenyl formazan derivative. The results obtained were interpreted in terms of electrophilic and nucleophilic nature of substituent attached to aryl group.

Keywords: Formazan derivative, Viscosity, Conductivity, Antimicrobial activity.