Abstract: A series of metal [Cu(II) and Ni(II) complexes have been prepared with an azo ligand, 2-{E-[4-hydroxyphenyl)imino]methyl}phenol(SB1) derived from the Aminophenol nucleus synthesized and along with their complexes were characterized by investigating various spectroscopic and analytical techniques such as UV-Vis, FTIR, 1H NMR, powder- XRD and TGA. The azomethine ligand and its mixed ligand complexes have been investigated for their antimicrobial, anticancer, and DNA binding studies. These tested compounds showed moderate to good antimicrobial activity compared with the standards. MIC studies have revealed that the SB1 ligand is more effective against pathogens.
In addition, all the prepared compounds exhibited a significant groove-binding property to the CT-DNA.

Article info

Keywords: Aminophenol, acetaminophen, Antimicrobial, Molecular docking

| DOI: 10.17148/IARJSET.2022.9263