Abstract: Ethyl-3-oxo-2-(2-(4-sulfamoylphenyl)hydrazono) butanoate (2) on condensation with 6-methyl-2-oxo-4-subsituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carbohydrazide (3a-e) to gave 4-(2-(3-methyl-1-(6-methyl-2-oxo-4-subsituted phenyl-1,2,3,4-tetrahydro pyrimidine -5-carbonyl)-5-oxo-1H-pyrazol-4(5H)-ylidene) hydrazine) benzene sulfonamide (4a-e), which on reaction with benzaldehyde gives 4-(2-(1-(4-([1,1'-biphenyl]-4-yl)-3-(hydroxyl (phenyl) aryl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl) benzenesulfonamide(5a-e).The structures of all these compounds (4a-e) were recognized by analytical and spectral studies. The synthesized compounds were evaluated for their antimicrobial activity against various bacteria and fungi. 

Keywords: Sulphadrug, Pyrazole and Antimicrobial Activity

| DOI: 10.17148/IARJSET.2019.6108